The Synthesis and Antimicrobial Activity of Some 6-chloro-2-Aminobenzothiazoles and Corresponding Schiff Bases

Abstract

Para-Chloro aniline is readily converted to 6-chloro-2-aminobenzothiazole by reaction with potassium thiocyanate and bromine in glacial acetic acid. The arylamino acetyl chloride obtained from reaction between arylamine with chloro acetyl chloride. The product arylamino acetyl chloride was allowed to react with- 6-chloro-2-aminobenzothiazole to produce N- aryl- N̄ -6-chloro-2-aminobenzothiazole acetyl chloride.

Coupling reaction of 6-chloro-2-aminobenzothiazole with substituted benzaldehyde gave corresponding Schiff bases. The synthesized compounds have been characterized on the basis of IR spectral analysis and the results are compatible with their assigned structures. Derivative compounds syntheses were experienced in vitro for their antimicrobial activity against variety types of bacteria and fungal. The results were indicated the moderate and good level of inhibition for microbial growth from all tested compounds.