Synthesis and Characterization of Pharmacologically Important Acetylenic Amines Derived from Piperazine

Abstract

Acetylenic amines are very important class of compounds for their pharmacological properties such as activity, low toxicity and easy to absorption from the body. More over these compounds are electron rich and easy to bond with receptor protein.

A number of pharmacologically important acetylenic amines derived from piperazine with expected activity as oxotremorine antagonist have been synthesized through Mannich reaction⁽¹⁾. The compounds prepared by reaction of para aromatic substituting propynes with piprazine derivatives and formaldehyde in the presence of cuprous chloride as a catalyst. All the prepared compounds are characterized by elemental analysis and spectroscopic methods, the all physical and spectral data are showed in tables (1-3).