Synthesis of some new 3-chloro-4-aryl-2-azitidinone

Abstract

2-amino benzothiazole ($A_1$) were synthesized by the reaction of p-toludine with potassium thiocynate in presence of bromine , the reaction of compound ($A_1$) with hydrazine hydrate and hydrochloric acid in the ethylene glycol gave 2-hydrazinobenzothiazole ($A_2$). The compounds ($A_{3-7}$) were synthesized by the reaction of 2-hedrazinobenzothiazole with substituted benzaldehyde . 3-chloro-4-aryl-2-azitidinone ($A_{8-12}$) were synthesized by the reaction of compound ($A_{3-7}$) with chloro acetyl chloride in presence of triethyl amine. The structures of the synthesized compounds were confirmed by I.R, $^1\text{H-NMR}$ and $^{13}\text{C-NMR}$ spectra and Some chemical and physical data.