Immunological role of Probiotic in treatment of Helicobacter Pylori Infection

Abstract

Helicobacter pylori is the most common cause of acute chronic mucosal tumors, peptic ulcer, gastric carcinoma, duodenitis and gastritis. The current work aim to know the effect of probiotics in the treatment of patients with Helicobacter pylori and measuring the levels of MCP-1, IL-10 of these patients before and after treatment. The work was conducted in the laboratory of Al_Sharqat Hospital in Salah Al-din governorate, stool and blood samples were collected from 80 patients at ages between (29-59) years, during the period between November 2021 to May 2022.

The study include 80 serum samples were collected from the patients and this samples were devided to two groups first include 40 patients treated with probiotic while other group 40 patients treated with antibiotic, , the levels of IL- 10 and MCP-1 investigated By using ELISA technique to determine acute infection,. According to 61 stool were collected from patient were infected with Helicobacter pylori, 35 (87.5%) patients were treated with probiotics succeeded in eradicating Helicobacter pylori, while 26 (65%) patients were treated with antibiotics.

The result show differences in the level of MCP-1 and IL-10 of patients were treated by probiotics, the levels of MCP-1 increased from 78.07 to 91.18 pg\ml after treatments, in contrast to levels of IL-10 before treatments