The effect of organic extract of the plant Zand al-Arus on fatty acids in the cholesterol ester fraction of rats with induced diabetes

Abstract

This study dealt with the extraction of a number of active compounds from the Ammi majus plant through three extracts (organic, alcoholic, and aqueous). Then, these extracts were used on five groups of rats infected with alloxan-induced diabetes. These groups were (normal control, positive control, and three groups treated with the extracts). The percentage of fatty acids of all types, saturated, monounsaturated, and polyunsaturated, in the blood serum of the five groups above was monitored. Significant differences were observed in the percentage of fatty acids of all types in the three parts of the blood serum: cholesterol ester, triglycerides, and phospholipids, when comparing the control groups with the groups of infected rats treated with the extracts. The results showed that the organic extract was the best type of extract due to its content of several important compounds, such as apigenin, p-coumaric acid, sinapic acid, and ferulic acid. These compounds had a positive effect on improving the percentage of unsaturated fatty acids in the three parts of blood serum.