In vitro Comparison of the Effect of Zinc Oxide Nanoparticles and Hibiscus sabdariffa Extract on Streptococcus mutans Isolated from Human Dental Caries

Abstract

Streptococcus mutans has been linked to dental cavities, a global public health issue. This is considered the possible cause of infection. Nanotechnology has recently been used to create unique material characteristics. The study compares the effects of aqueous and alcoholic Hibiscus extracts, as well as zinc oxide nanoparticles, on S. mutans obtained from the dental cavity. Hibiscus and zinc are widely utilized in conventional therapies, along in addition to the production of dental care products to overcome the bacterial antibiotic resistance issue. Findings have shown that Hibiscus and small amounts of nano zinc oxide had a good efficacy towards S. mutans. To correlate zinc to the rest of the nanoparticles, it possesses a strong attachment readiness for hommed tissue which could not get damaged via zinc. In this research, the anti-bacterial effect of different amounts of ZnO NPs, and Hibiscus extract against 31 S. mutans dental isolates. The effective sensitivity test that has been conducted along in addition to the rise of mount ZnO NPs, and the Hibiscus extract showed great efficacy. ZnO NPs showed an MIC of 0.312 mg/ml while the alcoholic and aqueous extract of Hibiscus showed an MIC of 12.5, 25mg/ml, respectively against S. mutans.