Synthesis, Characterization, Molecular Docking Studies and Biological Evaluation of Oxazolidine-5-one Schiff Base Analogs

Abstract

In vitro tests were conducted to determine the likely antibacterial activities of a novel class of 2-aminobenzothiazole compounds that had been substituted.  Chloroacetic acid and prepared Schiff bases were combined to create new oxazolidin-5-one compounds with dioxane acting as a solvent.  The reaction was monitored and described using the melting point, yield, and color during the sublimation method of preparation. Proton and carbon nuclear magnetic resonance (¹H&¹³C-NMR), thin-layer chromatography (TLC), infrared spectroscopy (FT-IR), and quantitative elemental analysis (C.H.N.) were used to determine whether the reaction was completed.  Among all the compounds created, W1 was more effective than ampicillin at 0.01 μg/ml against both Gram-positive (Staph. epidermidis) and Gram-negative (K. pneumoniae) bacteria. The compounds W4 and W7 were the most effective against Staphylococcus epidermidis. The produced compounds showed moderate to high antibacterial activity, according to the results. Compound W1, according to molecular docking studies and in vitro antibacterial activity, is a promising drug for the treatment of Staph. epidermidis.   W4 and W7 compounds demonstrated antimicrobial properties. According to molecular docking studies, oxazolidin-5-one analogs bonded well to putative receptor binding sites